Insights on the therapeutic use of ivermectin: Mechanism of action and histopathological effects

Authors

  • Moustafa S. Abou El-Fetouh Department of Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
  • Nora M. Elseddawy Department of Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
  • Hagar M. Abdelsamia Bachlor of Veterinary Medical Sciences, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

Keywords:

Ivermectin, Histopathology , Mechanism of action

Abstract

Ivermectin is a broad-spectrum antiparasitic drug with outstanding efficacy and a wide margin of safety. This drug has been widely utilized in veterinary medicine since 1987, and its use in humans has grown. Ivermectin is a broad-spectrum anti-parasitic agent licensed by the FDA. Ivermectin is a mixture of 80% or more avermectin B1a (AB1a) analogue and 20% or less avermectin B1b analogue. Iverzine has been proven to have widespread antiviral action in recent years. Ivermectin has also a broad-spectrum activity against the viruses that cause dengue, Zika, HIV, and yellow fever in vitro. Despite this in vitro action, no clinical trials have shown that ivermectin has a therapeutic benefit in patients with these viruses. Some ivermectin studies have also revealed potential anti-inflammatory qualities, which may be beneficial in persons with COVID-19. However, the use of ivermectin in animals was also associated with some histopathological effects in the internal organs including the liver, kidney, spleen, and brain. The purpose of this review was to provide light on the mechanism of action of ivermectin and its related histopathological consequences in various animal species.

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Published

2024-02-09

How to Cite

Abou El-Fetouh, M. S. ., Elseddawy, N. M. ., & Abdelsamia, H. M. . (2024). Insights on the therapeutic use of ivermectin: Mechanism of action and histopathological effects. Journal of Advanced Veterinary Research, 14(2), 339-341. Retrieved from https://www.advetresearch.com/index.php/AVR/article/view/1530